Adler F L, Noelle R J
J Immunol. 1975 Sep;115(3):620-5.
A majority of rabbits born to mothers heterozygous with respect to the b locus allotypic markers "spontaneously" develop antibodies against the noninherited maternal allotypes. Such antibodies generally appear in the 4- to 5-month-old rabbit, after what may be a transient period of tolerance, and persist at constant levels for at least 5 to 6 months. The finding of a high incidence of measurable antimaternal allotype responses in "normal" rabbits, added to similar findings by others in mice, pigs, and man, underscores the generality of this rather unexpected phenomenon and invites further inquiries into biological significance.
对于b位点同种异型标记杂合的母兔所生的大多数兔子，会“自发”产生针对非遗传的母本同种异型的抗体。此类抗体通常在4至5月龄的兔子中出现，此前可能有一个短暂的耐受期，并且会以恒定水平持续至少5至6个月。在“正常”兔子中发现可检测到的抗母本同种异型反应的高发生率，再加上其他人在小鼠、猪和人类中的类似发现，突出了这种相当意外的现象的普遍性，并引发了对其生物学意义的进一步探究。
