自然诱导的自身抗独特型抗体。由远交兔家族某些成员中的相同独特型表位诱导产生。
Naturally induced auto-anit-idiotypic antibodies. Induction by identical idiotopes in some members of an outbred rabbit family.
作者信息
Binion S B, Rodkey L S
出版信息
J Exp Med. 1982 Sep 1;156(3):860-72. doi: 10.1084/jem.156.3.860.
Naturally induced auto-anti-idiotypic (AAI) antibody responses specific for antimicrococcal antibody idiotypes were detected in 42% of the rabbits in a family immunized with Micrococcus lysodeikticus. The natural AAI response of each rabbit recognized only a portion (11-41%) of that individual's total antimicrococcal antibody population. Cross-reactions of idiotypes were observed within the group of rabbits exhibiting natural AAI responses. Examination of the basis for the cross-reactions showed that the natural AAI antisera recognized identical idiotopes on the antimicrococcal F(ab')2 fragments from each rabbit that made an AAI response. The cross-reactive idiotopes were shown to be of paternal origin and were found in the antimicrococcal antibodies of each offspring. The data strongly support the idiotypic network concept that naturally induced AAI responses may occur routinely in outbred normal individuals as a result of antigenic stimulation. Further, the data suggest that the induction of regulatory AAI antibody responses in outbred rabbits may depend on the expression of particular germ line idiotopes.
在用溶壁微球菌免疫的一个家系的兔子中，42%检测到了针对抗微球菌抗体独特型的自然诱导自身抗独特型（AAI）抗体反应。每只兔子的自然AAI反应仅识别该个体总抗微球菌抗体群体的一部分（11%-41%）。在表现出自然AAI反应的兔子群体中观察到了独特型的交叉反应。对交叉反应基础的研究表明，自然AAI抗血清识别来自每只产生AAI反应兔子的抗微球菌F(ab')2片段上相同的独特位。交叉反应独特位显示为父本来源，并在每个后代的抗微球菌抗体中发现。这些数据有力地支持了独特型网络概念，即由于抗原刺激，自然诱导的AAI反应可能在远交正常个体中经常发生。此外，数据表明在远交兔子中诱导调节性AAI抗体反应可能取决于特定种系独特位的表达。
Zotero 插件