Levy M L, Miller B L, Cummings J L, Fairbanks L A, Craig A
Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles School of Medicine, USA.
Arch Neurol. 1996 Jul;53(7):687-90. doi: 10.1001/archneur.1996.00550070129021.
Frontotemporal dementia (FTD) is a syndrome produced by lobar degeneration of the temporal and/or frontal lobes.
To quantify the behavioral disturbances of FTD and compare them with behavioral changes observed in Alzheimer disease (AD).
Cross-sectional comparison of 2 groups defined by research diagnostic criteria and single photon emission computed tomography. Behaviors were assessed using a standardized rating scale-Neuropsychiatric Inventory. Groups were matched for dementia severity.
Patients were seen at 2 university-based outpatient dementia clinics and a Veterans Affairs medical center.
Twenty-two patients with FTD and 30 patients with AD.
Patients with FTD had significantly greater total Neuropsychiatric Inventory scores than patients with AD and exhibited more apathy, disinhibition, euphoria, and aberrant motor behavior. The Neuropsychiatric Inventory accurately assigned 77% of patients with FTD and 77% of patients with AD to the correct diagnostic group using disinhibition, apathy, and depression. Patients with FTD had higher levels of disinhibition and apathy with relatively lower levels of depression compared with patients with AD.
The Neuropsychiatric Inventory provides a behavioral profile that differentiates patients with FTD from patients with AD. Patients with FTD are more behaviorally disturbed but are often less depressed than patients with AD relative to their level of apathy.
额颞叶痴呆（FTD）是一种由颞叶和/或额叶叶性变性引起的综合征。
量化FTD的行为障碍，并将其与阿尔茨海默病（AD）中观察到的行为变化进行比较。
根据研究诊断标准和单光子发射计算机断层扫描对两组进行横断面比较。使用标准化评分量表——神经精神科问卷评估行为。两组在痴呆严重程度上进行匹配。
患者在两家大学门诊痴呆诊所和一家退伍军人事务医疗中心就诊。
22例FTD患者和30例AD患者。
FTD患者的神经精神科问卷总分显著高于AD患者，表现出更多的冷漠、脱抑制、欣快和异常运动行为。神经精神科问卷使用脱抑制、冷漠和抑郁将77%的FTD患者和77%的AD患者准确地分配到正确的诊断组。与AD患者相比，FTD患者的脱抑制和冷漠水平较高，而抑郁水平相对较低。
神经精神科问卷提供了一种行为特征，可将FTD患者与AD患者区分开来。相对于冷漠程度，FTD患者的行为障碍更严重，但抑郁程度通常低于AD患者。
