Yukiiri K, Mizushige K, Ueda T, Kohno M
Second Department of Internal Medicine, Kagawa Medical University, Kita, Japan.
Angiology. 2001 Aug;52(8):563-5. doi: 10.1177/000331970105200810.
A 76-year-old man was found to have esophageal squamous cell carcinoma and had been treated with radiational therapy and chemotherapy. Five years later, he was readmitted with dyspnea and marked edema of his extremities and face. An echocardiographic examination revealed a mass lesion in the pericardium with pericardial effusion behind the left ventricular posterior wall, which was near the site of the original esophageal cancer. Coronary arteriography revealed a feeder artery to the mass from the left circumflex branch. No findings indicated a recurrence of the esophageal cancer; cytologic studies showed malignant lymphoma cells of B-cell origin. A second primary cancer of some organs including blood cells might be induced by the carcinogenic effects of ionizing radiation or chemotherapeutic agents. This is the first case of second primary cardiac B-cell lymphoma after combination therapy.
一名76岁男性被诊断为食管鳞状细胞癌，并接受了放射治疗和化疗。五年后，他因呼吸困难以及四肢和面部明显水肿再次入院。超声心动图检查显示心包有一个肿块病变，左心室后壁后方有心包积液，该部位靠近原食管癌部位。冠状动脉造影显示肿块有一条来自左旋支的供血动脉。没有发现表明食管癌复发；细胞学研究显示为B细胞起源的恶性淋巴瘤细胞。电离辐射或化疗药物的致癌作用可能诱发包括血细胞在内的某些器官发生第二原发性癌症。这是联合治疗后发生第二原发性心脏B细胞淋巴瘤的首例病例。
