Lebowitz B K, Shear P K, Steed M A, Strakowski S M
Department of Psychology, University of Cincinnati, Ohio 45221, USA.
Neuropsychiatry Neuropsychol Behav Neurol. 2001 Jul-Sep;14(3):177-82.
The objective of this study was to examine verbal fluency in a group of patients with bipolar disorder (BPD) during an acute episode of mania, and to determine whether performance was related to disease chronicity. We hypothesized that manic patients with BPD would be impaired on verbal fluency, and that this impairment would be greatest in those individuals who had experienced a greater number of manic episodes.
Forty-five manic inpatients with bipolar disorder, and 30 healthy volunteers completed tests of phonemic and semantic verbal fluency. The patients were dichotomized into those experiencing their first episode of mania (FE) and those who had experienced multiple episodes (ME).
On the phonemic fluency task, ME patients produced significantly fewer words than both healthy volunteers and FE patients, and they made a greater number of errors. No significant group differences in overall output were found on the semantic fluency task, although the ME group was more error-prone than were the other groups.
These findings suggest that verbal fluency is more impaired in ME patients than in patients who have experienced only a single manic episode.
本研究的目的是检查一组双相情感障碍（BPD）患者在躁狂急性发作期间的言语流畅性，并确定其表现是否与疾病慢性程度相关。我们假设患有BPD的躁狂患者在言语流畅性方面会受损，并且这种损害在经历过更多躁狂发作的个体中最为严重。
45名双相情感障碍的躁狂住院患者和30名健康志愿者完成了音素和语义言语流畅性测试。患者被分为首次经历躁狂发作的患者（FE）和经历过多次发作的患者（ME）。
在音素流畅性任务中，ME组患者说出的单词明显少于健康志愿者和FE组患者，并且他们犯的错误更多。在语义流畅性任务中，虽然ME组比其他组更容易出错，但在总体输出方面未发现显著的组间差异。
这些发现表明，与仅经历过一次躁狂发作的患者相比，ME组患者的言语流畅性受损更严重。
