Lubin D A, Meter K E, Walker C H, Johns J M
Department of Psychology, University of North Carolina at Chapel Hill, 27599, USA.
Prog Neuropsychopharmacol Biol Psychiatry. 2001 Oct;25(7):1421-33. doi: 10.1016/s0278-5846(01)00196-8.
Virgin Sprague-Dawley rats received subcutaneous injections of saline, 3.5, 7.5 or 15 mg/kg of cocaine, twice daily, for 20 consecutive days. Females were videotaped for 10 minutes in the presence of a male rat for assessment of aggression towards the intruder 2, 3, and 5 days following cessation of cocaine or saline administration. Oxytocin levels in discrete brain areas were assayed following behavioral testing, 5 days following cessation of cocaine or saline administration. The 30 mg/kg-dose group tended to have a lower frequency of fight attacks and aggressive postures compared to saline-treated controls across sessions. The frequency of most of the behaviors analyzed were represented by quadratic functions across time, such that the highest frequency of behavior occurred 2 days following the final injection with relatively less activity 3 and 5 days following cessation of saline or cocaine administration. The 30 mg/kg cocaine-treated group had significantly lower hippocampal OT levels than the 15 mg/kg group 5 days following cessation of cocaine or saline administration.
将初产的斯普拉格-道利大鼠每天皮下注射生理盐水、3.5、7.5或15毫克/千克可卡因，每日两次，连续注射20天。在停止给予可卡因或生理盐水后的第2、3和5天，将雌性大鼠置于雄性大鼠面前录像10分钟，以评估其对入侵者的攻击性。在行为测试后，即停止给予可卡因或生理盐水后的第5天，测定离散脑区的催产素水平。与生理盐水处理的对照组相比，30毫克/千克剂量组在各时间段的打斗攻击和攻击姿势频率往往较低。分析的大多数行为的频率随时间呈二次函数变化，使得行为的最高频率出现在最后一次注射后的第2天，而在停止给予生理盐水或可卡因后的第3天和第5天活动相对较少。在停止给予可卡因或生理盐水后的第5天，30毫克/千克可卡因处理组的海马催产素水平显著低于15毫克/千克组。
