van Wimersma Greidanus T B, Maigret C
Rudolf Magnus Institute for Neurosciences, Department of Pharmacology, Utrecht University, The Netherlands.
Brain Res. 1996 Mar 25;713(1-2):153-9. doi: 10.1016/0006-8993(95)01505-1.
Young male rats were exposed two times for 5 min, to older male rats with an interval of 30 min in the anti-vasopressin serum experiments and with an interval of 120 min in the anti-oxytocin serum experiments. The time spent by the older rats with social investigation of the younger animal was scored during the two encounters. In placebo-treated animals the time spent on social investigation of the younger animal during the second encounter at 30 min is significantly shorter than during the first one (social recognition). However, intracerebroventricular or local application of anti-vasopressin serum in the dorsal or ventral hippocampus or in the dorsal septal area, but not in the n. olfactorius, results in similar periods of time spent for social investigation during the two encounters. Thus, endogenous vasopressin in the dorsal and ventral hippocampus and in the dorsal septal region plays a physiological role in social recognition/memory. In placebo-treated rats the time spent on social investigation of the younger animal during the second encounter at 120 min is similar to that during the first encounter. However, local administration of anti-oxytocin serum in the ventral hippocampus, but not in the dorsal hippocampus, nor in the n. olfactorius or the septal area, results in shorter investigation times during the second encounter. Thus, taken together the presence or local release of vasopressin and oxytocin in the ventral hippocampus and that of vasopressin (but not oxytocin) in the dorsal hippocampus and dorsal septal area are of physiological importance for social recognition.
在抗加压素血清实验中，将年轻雄性大鼠与老年雄性大鼠接触两次，每次5分钟，间隔30分钟；在抗催产素血清实验中，间隔为120分钟。在两次接触期间，记录老年大鼠对年轻动物进行社会调查所花费的时间。在接受安慰剂治疗的动物中，30分钟时第二次接触期间对年轻动物进行社会调查所花费的时间明显短于第一次接触（社会识别）。然而，在背侧或腹侧海马体或背侧隔区而非嗅神经中脑室内或局部应用抗加压素血清，会导致两次接触期间用于社会调查的时间相似。因此，背侧和腹侧海马体以及背侧隔区中的内源性加压素在社会识别/记忆中发挥生理作用。在接受安慰剂治疗的大鼠中，120分钟时第二次接触期间对年轻动物进行社会调查所花费的时间与第一次接触时相似。然而，在腹侧海马体而非背侧海马体、嗅神经或隔区局部注射抗催产素血清，会导致第二次接触期间的调查时间缩短。因此，综合来看，腹侧海马体中加压素和催产素的存在或局部释放以及背侧海马体和背侧隔区中加压素（而非催产素）的存在对社会识别具有生理重要性。
