Riggs J E
Departments of Neurology, Medicine, and Community Medicine, West Virginia University School of Medicine, Morgantown, WV, USA.
Mil Med. 2001 Aug;166(8):731-2.
Traumatic axonal injury-induced apoptotic motor neuron cell death in neonatal rats is an established animal model used to study potential therapeutic agents in amyotrophic lateral sclerosis (ALS). In an analogous manner, trauma causing motor neuron axonal injury (which included focal neuropathy, plexopathy, and radiculopathy) preceded the onset of ALS in nine young adult men (age range, 28-43 years). The latency between the traumatic axonal injury and the onset of ALS symptoms in these patients ranged from 5 to 42 months (mean, 14.6 months).
创伤性轴突损伤诱导新生大鼠运动神经元细胞凋亡死亡是一种既定的动物模型，用于研究肌萎缩侧索硬化症（ALS）的潜在治疗药物。同样，在9名年轻成年男性（年龄范围为28 - 43岁）中，导致运动神经元轴突损伤（包括局灶性神经病、臂丛神经病和神经根病）的创伤先于ALS发病。这些患者创伤性轴突损伤与ALS症状发作之间的潜伏期为5至42个月（平均14.6个月）。
