Gallagher J P, Sanders M
Acta Neurol Scand. 1987 Feb;75(2):145-50. doi: 10.1111/j.1600-0404.1987.tb07909.x.
This was a controlled study to assess the possible role of mechanical trauma in the pathogenesis of some cases of amyotrophic lateral sclerosis (ALS). Questionnaires were sent to 181 patients with ALS who had developed the disease before age 45. Among the 135 respondents 78 (58%) reported having sustained injuries severe enough to have required medical attention prior to the onset of their motor neuron illness. Fifty nine (76%) of the ALS patients reporting an earlier trauma had incurred an injury to the head, neck, shoulder and/or arm. For controls, we used the 85 patients with multiple sclerosis who responded to the questionnaires sent them. The findings of this investigation add further evidence that a former injury may be important in the etiology of some cases of ALS developing early in life.
这是一项对照研究，旨在评估机械性创伤在某些肌萎缩侧索硬化症（ALS）病例发病机制中的可能作用。我们向181名45岁之前发病的ALS患者发放了问卷。在135名回复者中，78人（58%）报告称在运动神经元疾病发病前受过严重到需要就医的损伤。报告曾有过早期创伤的ALS患者中，59人（76%）头部、颈部、肩部和/或手臂受过伤。作为对照，我们选取了85名回复问卷的多发性硬化症患者。这项调查结果进一步证明，既往损伤可能在一些早年发病的ALS病例病因中起重要作用。
