Riggs J E
Department of Neurology, West Virginia University School of Medicine, Morgantown 26506.
Mil Med. 1993 Jan;158(1):55-7.
Antecedent trauma has been implicated as a risk factor for many neurologic disorders, including amyotrophic lateral sclerosis (ALS). Aging is a dynamic, exponentially increasing risk factor for many disorders, also including ALS. Consequently, the relative significance of other risk factors diminishes correspondingly with increasing age. Gompertzian risk analysis suggests that only in a young susceptible individual could the age-dependent risk be low enough to relate the development of ALS to a non-age-dependent risk factor, such as preceding trauma. This point is illustrated by the case histories of three young adult men who developed ALS within 2 years following trauma.
既往创伤已被认为是包括肌萎缩侧索硬化症（ALS）在内的许多神经系统疾病的危险因素。衰老是包括ALS在内的许多疾病的一个动态的、呈指数增长的危险因素。因此，随着年龄的增长，其他危险因素的相对重要性相应降低。冈珀茨风险分析表明，只有在年轻易感个体中，年龄依赖性风险才可能低到足以将ALS的发生与非年龄依赖性危险因素（如既往创伤）联系起来。三名年轻成年男性在创伤后2年内患上ALS的病例史说明了这一点。
