Degenhardt L, Hall W, Lynskey M
National Drug and Alcohol Research Centre, University of NSW, Sydney, Australia.
Soc Psychiatry Psychiatr Epidemiol. 2001 May;36(5):219-27. doi: 10.1007/s001270170052.
This study aimed to examine the patterns of association between cannabis use, and anxiety and affective disorders, in the general population.
Data from the Australian National Survey of Mental Health and Well-Being, a representative survey of Australians aged 18 years and over, were analysed to address the following questions: (1) is there an association between cannabis use, DSM-IV abuse and dependence, and DSM-IV affective and anxiety disorders; (2) if so, is it explained by: demographic characteristics, levels of neuroticism, or other drug use; and (3) does the presence of a comorbid affective or anxiety disorder affect the likelihood of treatment seeking among cannabis users?
There was a moderate univariate association between involvement with cannabis use in the past 12 months and the prevalence of affective and anxiety disorders. Among those with DSM-IV cannabis dependence, 14% met criteria for an affective disorder, compared to 6% of non-users; while 17% met criteria for an anxiety disorder, compared to 5% of non-users. These associations did not remain significant after including demographics, neuroticism and other drug use in multiple regressions.
Cannabis use did not appear to be directly related to depression or anxiety when account was taken of other drug use. However, the association between heavier involvement with cannabis use and affective and anxiety disorders has implications for the treatment of persons with problematic cannabis use.
本研究旨在调查普通人群中大麻使用与焦虑及情感障碍之间的关联模式。
对澳大利亚全国心理健康与幸福调查的数据进行分析,该调查是对18岁及以上澳大利亚人的代表性调查,以解决以下问题:(1)大麻使用、《精神疾病诊断与统计手册》第四版(DSM-IV)中的滥用和依赖与DSM-IV情感及焦虑障碍之间是否存在关联;(2)如果存在关联,是否可由以下因素解释:人口统计学特征、神经质水平或其他药物使用情况;(3)共病的情感或焦虑障碍是否会影响大麻使用者寻求治疗的可能性?
在过去12个月中参与大麻使用与情感及焦虑障碍患病率之间存在中等程度的单变量关联。在符合DSM-IV大麻依赖标准的人群中,14%符合情感障碍标准,而非使用者中这一比例为6%;17%符合焦虑障碍标准,而非使用者中这一比例为5%。在多元回归中纳入人口统计学、神经质和其他药物使用情况后,这些关联不再显著。
在考虑其他药物使用情况时,大麻使用似乎与抑郁或焦虑无直接关联。然而,大麻使用程度较高与情感及焦虑障碍之间的关联对有问题的大麻使用者的治疗具有启示意义。