Brodey R S
Yale J Biol Med. 1979 Jul-Aug;52(4):345-61.
For many years, research into human cancer has concentrated on human patients and on artificially induced neoplasms in inbred murine hosts. Cancer, however, affects a great variety of mammals, particularly those that have been domesticated. Suchf naturally occurring neoplasms are common in dogs, cats, cattle, horses, etc., and offer fertile ground for studies relating to epidemiologyf, etiology, immunobiology, and therapy. Canine osteosarcoma is described in detail. The clinicopathologic features of this canine tumor closely approximate that of human osteosarcoma and thus make canine osteosarcoma an invaluable comparative model. Canine osteosarcoma and other naturally occurring tumors lie intermediate between the mouse models and human cancer. The use of these veterinary models in the future fabric of cancer research will broaden its base and will influence our conceptual approach to research and clinical options.
多年来，对人类癌症的研究主要集中在人类患者以及近交系小鼠宿主中人工诱导的肿瘤上。然而，癌症会影响多种哺乳动物，尤其是那些已被驯化的动物。这种自然发生的肿瘤在狗、猫、牛、马等动物中很常见，为有关流行病学、病因学、免疫生物学和治疗的研究提供了丰富的素材。本文详细描述了犬骨肉瘤。这种犬类肿瘤的临床病理特征与人类骨肉瘤非常相似，因此使犬骨肉瘤成为一个极其宝贵的比较模型。犬骨肉瘤和其他自然发生的肿瘤介于小鼠模型和人类癌症之间。在未来的癌症研究架构中使用这些兽医模型将拓宽其基础，并将影响我们的研究概念方法和临床选择。
