钙离子对控制横纹肌突触处乙酰胆碱释放的二项式统计参数的影响。
The effect of calcium ions on the binomial statistic parameters which control acetylcholine release at synapses in striated muscle.
作者信息
Bennett M R, Florin T, Hall R
出版信息
J Physiol. 1975 May;247(2):429-46. doi: 10.1113/jphysiol.1975.sp010939.
Abstract
A study has been made of the effects of changing [Ca]O and [Mg]O on the binomial statistic parameters p and n which control the average quantal content (m) of the synaptic potential due to acetylcholine release. 2. When [Ca]O was varied in the range 0-1 to 1-0 mM, p increased as the first power of [Ca]O whereas n increased as the third power of [Ca]O. 3. Increasing [Mg]O depressed both p and n, however variations of [Ca]O in the presence of high [Mg]O did not significantly change the power relationship between either p and [Ca]O or between n and [Ca]O. 4. The facilitated increase in m during a short train was due to an increase in n, whereas the post-tetanic increase in m during a tetanus was due to an increase in p. These results are considered in terms of the role of Ca ions in facilitation and post-tetanic potentiation.
摘要
研究了改变[Ca]O和[Mg]O对二项式统计参数p和n的影响，这两个参数控制着因乙酰胆碱释放而产生的突触电位的平均量子含量（m）。2. 当[Ca]O在0.1至1.0 mM范围内变化时，p随[Ca]O的一次幂增加，而n随[Ca]O的三次幂增加。3. 增加[Mg]O会使p和n都降低，然而在高[Mg]O存在的情况下改变[Ca]O，p与[Ca]O或n与[Ca]O之间的幂关系没有显著变化。4. 在短串刺激期间m的易化增加是由于n的增加，而在强直刺激期间强直后m的增加是由于p的增加。根据钙离子在易化和强直后增强中的作用对这些结果进行了讨论。
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本文引用的文献
1
An analysis of facilitation of transmitter release at the neuromuscular junction of the frog.对青蛙神经肌肉接头处递质释放促进作用的分析。
J Physiol. 1967 Dec;193(3):679-94. doi: 10.1113/jphysiol.1967.sp008388.
2
REPETITIVE STIMULATION AT THE MAMMALIAN NEUROMUSCULAR JUNCTION, AND THE MOBILIZATION OF TRANSMITTER.哺乳动物神经肌肉接头处的重复刺激与递质的动员
J Physiol. 1963 Dec;169(3):641-62. doi: 10.1113/jphysiol.1963.sp007286.
3
Movements of labelled calcium in squid giant axons.标记钙在枪乌贼巨大轴突中的移动。
J Physiol. 1957 Sep 30;138(2):253-81. doi: 10.1113/jphysiol.1957.sp005850.
4
The nature of the antagonism between calcium and magnesium ions at the neuromuscular junction.神经肌肉接头处钙离子与镁离子之间拮抗作用的本质。
J Physiol. 1957 Oct 30;138(3):434-44. doi: 10.1113/jphysiol.1957.sp005860.
5
The action of calcium on the electrical properties of squid axons.钙对鱿鱼轴突电特性的作用。
J Physiol. 1957 Jul 11;137(2):218-44. doi: 10.1113/jphysiol.1957.sp005808.
6
A further study of the statistical composition on the end-plate potential.关于终板电位统计构成的进一步研究。
J Physiol. 1955 Oct 28;130(1):114-22. doi: 10.1113/jphysiol.1955.sp005397.
7
Co-operative action a calcium ions in transmitter release at the neuromuscular junction.钙离子在神经肌肉接头处递质释放中的协同作用。
J Physiol. 1967 Nov;193(2):419-32. doi: 10.1113/jphysiol.1967.sp008367.
8
Tetanic and post-tetanic rise in frequency of miniature end-plate potentials in low-calcium solutions.低钙溶液中微小终板电位频率的强直和强直后升高
J Physiol. 1971 Jan;212(1):245-57. doi: 10.1113/jphysiol.1971.sp009320.
9
Depolarization and calcium entry in squid giant axons.枪乌贼巨大轴突中的去极化和钙内流。
J Physiol. 1971 Nov;218(3):709-55. doi: 10.1113/jphysiol.1971.sp009641.
10
The formation of synapses in regenerating mammalian striated muscle.哺乳动物再生横纹肌中突触的形成。
J Physiol. 1974 Apr;238(1):79-92. doi: 10.1113/jphysiol.1974.sp010511.
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