Itoh Y
Department of Laboratory Medicine, Asahikawa Medical Collage, Asahikawa 078-8510.
Rinsho Byori. 2001 Jul;49(7):675-7.
Monoclonal protein is the immunoglobulin and its fragments which are originated from a monoclonal clone of immunoglobulin synthesizing cell. It is an actually tumour marker for B cell lymphoproliferative disorders. It is also observed in non-lymphoproliferative disorders such as solid tumor, infection, and immunodeficiencies. Monoclonal gammopathy of undetermined significance(MGUS) can be defined as a state of pre-malignancies, especially development of myeloma should be carefully followed. The paper outlines a routine-based laboratory approach on monoclonal protein in relevance with its classification, laboratory methods and the related diseases, thus giving general orientations for the paper followed.
单克隆蛋白是源自免疫球蛋白合成细胞单克隆克隆的免疫球蛋白及其片段。它实际上是B细胞淋巴增殖性疾病的肿瘤标志物。在实体瘤、感染和免疫缺陷等非淋巴增殖性疾病中也可观察到。意义未明的单克隆丙种球蛋白病（MGUS）可被定义为一种癌前状态，尤其应密切关注骨髓瘤的发展。本文概述了一种基于常规的实验室方法，涉及单克隆蛋白的分类、实验室方法及相关疾病，从而为后续论文提供总体方向。
