Díaz Flores M, Ortega-Camarillo C, Rosales-Torres A M, Baiza-Gutman L A, Hicks J J
Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI.
Gac Med Mex. 2001 Jul-Aug;137(4):291-302.
Ovulation is a complex process involving not only gonadotropins and steroid hormones, but also many local mediators common to inflammatory reactions, such as cytokines. Of particular interest is the ovarian interleukin-1 (IL-1) system, which may be an intermediary of gonadotropins in the ovulatory process. The preovulatory follicles have a complete and highly compartmentalized intraovarian IL-1 system including ligands, receptor, and receptor antagonist. IL-1 has been considered as the inductor of several ovulation-associated events such as prostaglandin and progesterone biosynthesis, plasminogen activator production, glycosaminoglycan generation, and enhancement of vascular permeability. The principal effector of the IL-1 system is nitric oxide. This paper analyzes the sites of synthesis and action of the IL-1 system in preovulatory follicle and its vascular dynamics as well as IL-1's mechanism of action in triggering follicular rupture.
排卵是一个复杂的过程，不仅涉及促性腺激素和甾体激素，还涉及许多炎症反应中常见的局部介质，如细胞因子。特别值得关注的是卵巢白细胞介素-1（IL-1）系统，它可能是促性腺激素在排卵过程中的中介物。排卵前卵泡具有完整且高度分隔的卵巢内IL-1系统，包括配体、受体和受体拮抗剂。IL-1被认为是几种与排卵相关事件的诱导剂，如前列腺素和孕酮的生物合成、纤溶酶原激活物的产生、糖胺聚糖的生成以及血管通透性的增强。IL-1系统的主要效应物是一氧化氮。本文分析了排卵前卵泡中IL-1系统的合成和作用位点及其血管动力学，以及IL-1触发卵泡破裂的作用机制。
