Gérard N, Caillaud M, Martoriati A, Goudet G, Lalmanach A-C
Physiologie de la Reproduction et des Comportements INRA-UMR 6073, Nouzilly, France.
J Endocrinol. 2004 Feb;180(2):203-12. doi: 10.1677/joe.0.1800203.
Interleukins (ILs) are known best for their involvement in the immune system and their role during inflammation. In the ovary, a growing body of evidence suggests that the ovarian follicle is a site of inflammatory reactions. Thus ovarian cells could represent sources and targets of ILs. Since then, the IL-1 system components (IL-1alpha, IL-1beta, IL-1 receptor antagonist, IL-1 receptors) have been demonstrated to have several sites of synthesis in the ovary. These factors have been localized in the various ovarian cell types, such as the oocyte, granulosa and theca cells, in several mammalian species. IL-1-like bioactivity has been reported in human and porcine follicular fluid at the time of ovulation. The role of IL-1 in local processes is still poorly known, although there is evidence for involvement in the ovulation process, and in oocyte maturation. More precisely, IL-1 may be involved in several ovulation-associated events such as the synthesis of proteases, regulation of plasminogen activator activity, prostaglandin and nitric oxide production. IL-1 also regulates ovarian steroidogenesis. These different aspects of the involvement of the IL-1 system in important aspects of female reproduction are discussed.
白细胞介素（ILs）因其参与免疫系统以及在炎症过程中的作用而最为人所知。在卵巢中，越来越多的证据表明卵巢卵泡是炎症反应的发生部位。因此，卵巢细胞可能是白细胞介素的来源和作用靶点。从那时起，白细胞介素-1系统的组成部分（白细胞介素-1α、白细胞介素-1β、白细胞介素-1受体拮抗剂、白细胞介素-1受体）已被证明在卵巢中有多个合成部位。在几种哺乳动物物种中，这些因子已定位在各种卵巢细胞类型中，如卵母细胞、颗粒细胞和卵泡膜细胞。在排卵时，人及猪的卵泡液中已报道有白细胞介素-1样生物活性。白细胞介素-1在局部过程中的作用仍知之甚少，尽管有证据表明其参与排卵过程和卵母细胞成熟。更确切地说，白细胞介素-1可能参与几个与排卵相关的事件，如蛋白酶的合成、纤溶酶原激活剂活性的调节、前列腺素和一氧化氮的产生。白细胞介素-1还调节卵巢类固醇生成。本文讨论了白细胞介素-1系统在女性生殖重要方面的不同参与情况。
