Golstein J, Vanhaelst L, Bruno O D, L'Hermite M
Acta Endocrinol (Copenh). 1979 Oct;92(2):205-13. doi: 10.1530/acta.0.0920205.
In order to investigate the effect of cyproheptadine, a compound with antiserotoninergic activity, on the secretion of thyrotrophin (TSH) and prolactin (PRL), the nocturnal secretory patterns of these hormones have been studied in 4 normal men in the basal state and after an oral treatment with the drug. In addition, the TSH and PRL responses to TRH of 6 women were compared in the basal conditions and after cyproheptadine treatment. The TSH nocturnal secretion was slightly modified by drug treatment. The response to TRH as well as the basal levels were comparable in the treated and non-treated subjects. In contrast, the PRL secretion measured through the nocturnal investigation was significantly inhibited by cyproheptadine administration as were the PRL basal levels in the TRH test. The PRL response to TRH was comparable in both situations.
为了研究具有抗血清素能活性的化合物赛庚啶对促甲状腺激素（TSH）和催乳素（PRL）分泌的影响，我们对4名处于基础状态的正常男性以及口服该药物后的男性，研究了这些激素的夜间分泌模式。此外，还比较了6名女性在基础状态和赛庚啶治疗后的TSH和PRL对促甲状腺激素释放激素（TRH）的反应。药物治疗对TSH夜间分泌有轻微改变。治疗组和未治疗组受试者对TRH的反应以及基础水平相当。相比之下，通过夜间调查测量的PRL分泌在赛庚啶给药后受到显著抑制，TRH试验中的PRL基础水平也是如此。两种情况下PRL对TRH的反应相当。
