Nakanishi T, Wakai K, Ishikawa H, Nawa A, Suzuki Y, Nakamura S, Kuzuya K
Department of Gynecology, Aichi Cancer Center Hospital, Nagoya, Japan.
Gynecol Oncol. 2001 Sep;82(3):504-9. doi: 10.1006/gyno.2001.6316.
The purpose of our study was to investigate a possible difference in ovarian metastasis between squamous cell carcinoma and adenocarcinoma of the uterine cervix and to confirm clinicopathological variables associated with the metastases.
Clinical and pathological variables of 1064 patients with invasive squamous cell carcinoma and 240 with adenocarcinoma were studied.
Ovarian metastasis was found in 14 patients (1.3%) with squamous cell carcinoma and 15 (6.3%) with adenocarcinoma. The mean age of patients with ovarian metastasis of squamous cell carcinoma was 57.4 years, compared to 50.2 years for adenocarcinoma. Ovarian metastasis of adenocarcinoma was more likely to be visible (40.0%) and present in both ovaries (66.7%), while these two characteristics occurred in only 21.4 and 36.7% of patients with squamous cell carcinoma. A logistic regression analysis with clinical variables indicated that clinical stage beyond IIb was a significant variable of squamous cell carcinoma, and more than 30-mm tumor size was significant in adenocarcinoma.
The incidence of ovarian metastasis of adenocarcinoma of the uterine cervix was significantly higher than that of squamous cell carcinoma. The incidence of adenocarcinoma was associated more closely with tumor size than clinical stage, whereas it was more associated with clinical stage in squamous cell carcinoma. The results thus suggested that the differences in ovarian metastases were caused by the different characteristics of the two types of carcinoma.
本研究旨在探讨子宫颈鳞状细胞癌和腺癌在卵巢转移方面的可能差异，并确定与转移相关的临床病理变量。
对1064例浸润性鳞状细胞癌患者和240例腺癌患者的临床和病理变量进行了研究。
鳞状细胞癌患者中有14例（1.3%）发生卵巢转移，腺癌患者中有15例（6.3%）发生卵巢转移。鳞状细胞癌发生卵巢转移患者的平均年龄为57.4岁，腺癌患者为50.2岁。腺癌的卵巢转移更易见（40.0%）且双侧卵巢均有转移（66.7%），而鳞状细胞癌患者中这两个特征的发生率分别仅为21.4%和36.7%。对临床变量进行逻辑回归分析表明，IIb期以上的临床分期是鳞状细胞癌的一个显著变量，肿瘤大小超过30mm对腺癌具有显著性。
子宫颈腺癌的卵巢转移发生率显著高于鳞状细胞癌。腺癌的发生率与肿瘤大小的相关性比与临床分期的相关性更密切，而鳞状细胞癌则更多地与临床分期相关。因此，结果表明卵巢转移的差异是由这两种类型癌症的不同特征所致。
