伴有甲状腺毒症的恶性卵巢甲状腺肿

Malignant struma ovarii with thyrotoxicosis.

作者信息

Matsuda K, Maehama T, Kanazawa K

机构信息

Department of Obstetrics and Gynecology, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.

出版信息

Gynecol Oncol. 2001 Sep;82(3):575-7. doi: 10.1006/gyno.2001.6315.

DOI:10.1006/gyno.2001.6315

PMID:11520159

Abstract

BACKGROUND

Malignant struma ovarii is seldom diagnosed preoperatively due to the rarity of the disease itself and the even rarer complications of thyrotoxicosis.

CASE

A 48-year-old woman presented with symptoms of hyperthyroidism and a pelvic tumor raising the possibility of ovarian malignancy. Hormonal findings revealed increased thyroid function, but the thyroid gland was normal in size and texture. Thus, she was diagnosed preoperatively as having a hormone-producing malignant struma ovarii. At surgery, a FIGO stage Ia ovarian papillary adenocarcinoma of the thyroid was found. An immunohistochemical tumor stain for thyroglobulin was positive and the ovarian venous thyroglobulin level was extremely high. Findings of hyperthyroidism disappeared over several weeks.

CONCLUSION

Malignant struma ovarii can be diagnosed preoperatively. Complications of thyrotoxicosis should be kept in mind when evaluating an ovarian tumor.

摘要

背景

由于恶性卵巢甲状腺肿本身罕见，且甲状腺毒症并发症更为罕见，术前很少能做出诊断。

病例

一名48岁女性出现甲状腺功能亢进症状和盆腔肿瘤，提示卵巢恶性肿瘤的可能性。激素检查结果显示甲状腺功能增强，但甲状腺大小和质地正常。因此，她术前被诊断为产生激素的恶性卵巢甲状腺肿。手术中发现了国际妇产科联盟（FIGO）Ia期甲状腺型卵巢乳头状腺癌。甲状腺球蛋白免疫组化肿瘤染色呈阳性，卵巢静脉甲状腺球蛋白水平极高。甲状腺功能亢进的症状在几周内消失。