Melberg P E, Ahlenius S, Engel J, Lundborg P
Psychopharmacology (Berl). 1976 Sep 17;49(2):119-23. doi: 10.1007/BF00427279.
A combined biochemical and behavioral study was performed postnatally on albino rats. An almost linear increase in total motor activity was observed from 1 to 15 days of age followed by a pronounced decrease in motor activity between days 15 and 18. The in vivo rate of tyrosine hydroxylase activity in whole brain was estimated by means of measuring accumulation of L-3,4-dihydroxyphenylalanine (Dopa) after administration of an inhibitor of aromatic amino acid decarboxylase NSD 1015. Additionally, Dopa accumulation was studied in regional brain areas in 10 and 14-day-old animals. A slight gradual increase in the amount of Dopa accumulation in whole brain was observed from 1 to 10 days of age, followed by a pronounced increase between 10 and 14 days. Regional studies revealed that the increase in Dopa accumulation was primarily located to striatum. The data suggest an involvement of central catecholamine neurons possibly dopaminergic, terminating in striatum. The decrease in motor activity observed after 15 days of age is interpreted as involvement of maturing inhibitory pathways of noncatecholaminergic origin.
对新生白化大鼠进行了一项结合生化和行为学的研究。从出生后第1天到第15天，观察到总运动活动几乎呈线性增加，随后在第15天到第18天运动活动明显下降。通过测量给予芳香族氨基酸脱羧酶抑制剂NSD 1015后L-3,4-二羟基苯丙氨酸（多巴）的积累，来估计全脑酪氨酸羟化酶活性的体内速率。此外，还研究了10日龄和14日龄动物脑区的多巴积累情况。从出生后第1天到第10天，全脑多巴积累量略有逐渐增加，随后在第10天到第14天显著增加。区域研究表明，多巴积累的增加主要位于纹状体。数据表明中枢儿茶酚胺神经元（可能是多巴胺能神经元）参与其中，其终末位于纹状体。出生后15天之后观察到的运动活动下降被解释为非儿茶酚胺能起源的成熟抑制通路的参与。
