Brosman S, Hausman M, Shacks S
J Urol. 1975 Jun;113(6):841-5. doi: 10.1016/s0022-5347(17)59594-4.
The state of cell-mediated immunity was evaluated in 41 patients with prostatic carcinoma by determining their ability to demonstrate delayed cutaneous hypersensitivity with dinitrochlorobenzene and recall antigens, and to mount an inflammatory response to croton oil, as well as by measuring changes in monocyte chemotactic response. The patients were divided into 2 groups: those with localized disease and those with metastatic carcinoma. Monocyte chemotactic response provides an in vitro quantitative measure of effector cell function and was significantly depressed in the entire group of prostatic cancer patients as compared to non-cancer controls (p less than 0.05). Patients with metastatic carcinoma had a greater defect than those with localized disease (p less than 0.025). After radical prostatectomy a group of patients with localized disease tended to show improvement in monocyte chemotactic response (p less than 0.025). The ability of patients to develop a delayed cutaneous hypersensitivity response was impaired and correlated with the clinical stage of the disease. By using the cutaneous irritant, croton oil, the ability of these cancer patients to mount an inflammatory response was also found to be impaired and showed a close correlation between clinical stage and course of disease. Changes in response to croton oil tended to precede alterations in dinitrochlorobenzene response.
通过检测41例前列腺癌患者对二硝基氯苯和回忆抗原表现出迟发型皮肤超敏反应的能力、对巴豆油产生炎症反应的能力以及测量单核细胞趋化反应的变化，来评估细胞介导免疫状态。患者分为两组：局限性疾病患者和转移性癌患者。单核细胞趋化反应提供了效应细胞功能的体外定量测量，与非癌症对照组相比，前列腺癌患者全组的单核细胞趋化反应显著降低（p<0.05）。转移性癌患者的缺陷比局限性疾病患者更大（p<0.025）。根治性前列腺切除术后，一组局限性疾病患者的单核细胞趋化反应有改善趋势（p<0.025）。患者产生迟发型皮肤超敏反应的能力受损，且与疾病的临床分期相关。通过使用皮肤刺激物巴豆油，还发现这些癌症患者产生炎症反应的能力受损，并且临床分期与病程之间存在密切相关性。对巴豆油反应的变化往往先于对二硝基氯苯反应的改变。
