Stefani S S, Menon M, Canning J R, Clark S S
J Urol. 1978 Oct;120(4):431-4. doi: 10.1016/s0022-5347(17)57215-8.
The immune competence of 65 patients with prostatic cancer was evaluated by 2 in vivo and 2 in vitro tests to study the contribution of host factors to the progress of the disease. Patients with benign prostatic hypertrophy served as controls. Our results indicate that the delayed skin hypersensitivity response to common microbial recall antigens (streptokinase/streptodornase, purified protein derivative, dermatophytin 0 and dermatophytin) is unaltered in advanced stages of malignancy. The ability to be sensitized by dinitrochlorobenzene declines significantly in patients with metastatic disease. Blastogenic response of peripheral blood lymphocytes to phytohemagglutinin stimulation is not depressed in late stages of malignancy, although in the circulating T cells per cent and absolute values are somewhat lower in patients with metastases. Herein we show that immune competence (measured by the 4 tests) of patients with prostatic carcinoma does not decrease markedly even in the late stages of the disease. Primary sensitization to dinitrochlorobenzene is the only test showing a decline in responsiveness related to the tumor stage.
通过两项体内试验和两项体外试验评估了65例前列腺癌患者的免疫能力，以研究宿主因素对疾病进展的影响。良性前列腺增生患者作为对照。我们的结果表明，在恶性肿瘤晚期，对常见微生物回忆抗原（链激酶/链道酶、纯化蛋白衍生物、癣菌素0和癣菌素）的迟发型皮肤超敏反应未发生改变。转移性疾病患者对二硝基氯苯致敏的能力显著下降。尽管转移患者的循环T细胞百分比和绝对值略低，但外周血淋巴细胞对植物血凝素刺激的增殖反应在恶性肿瘤晚期并未受到抑制。在此我们表明，即使在疾病晚期，前列腺癌患者的免疫能力（通过这四项试验测量）也不会明显下降。对二硝基氯苯的初次致敏是唯一一项显示反应性与肿瘤分期相关下降的试验。
