Oizumi T, Daimon M, Saitoh T, Kameda W, Yamaguchi H, Ohnuma H, Igarashi M, Eguchi H, Manaka H, Tominaga M, Kato T
Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan.
Diabetes Care. 2001 Sep;24(9):1579-83. doi: 10.2337/diacare.24.9.1579.
Despite a large number of studies, no association of the Trp64Arg polymorphism of the beta(3)-adrenergic receptor gene with obesity and type 2 diabetes has yet to be clearly elucidated. We examined the associations in a large population-based sample.
A total of 1,685 subjects (935 women and 750 men, aged 58.7 +/- 12.4 years) from a cohort population (n = 3,706) of the Funagata Diabetes Study were divided into three groups according to genotypes: Trp/Trp (n = 1,155), Trp/Arg (n = 486), and Arg/Arg (n = 44). Glucose tolerance was diagnosed according to the 1985 World Health Organization criteria. Subjects who had a BMI > or =30 kg/m(2) were considered obese. Associations with the traits related to obesity, diabetes, hypertension, and dyslipidemia were also examined. The chi(2) test and analysis of variance were used for the association studies and to assess the differences in the traits' values, respectively.
More subjects with genotype Arg/Arg were obese and had diabetes (13.6% for each) than those with genotype Trp/Trp (3.29%, P < 0.001; and 4.16%, P = 0.007, respectively) or genotype Trp/Arg (2.06%, P < 0.001; and 5.97%, P = 0.051, respectively). No significant differences in the frequencies of occurrence of these conditions were observed between genotypes Trp/Arg and Trp/Trp. Traits related to obesity, such as percent body fat (28.82 +/- 7.95 vs. 25.93 +/- 7.21, P = 0.038) and BMI (25.07 +/- 3.84 vs. 23.63 +/- 3.18, P = 0.018), were higher in the genotype Arg/Arg than in the genotype Trp/Trp groups.
Genotype Arg/Arg, but not Trp/Arg, of the beta(3)-adrenergic receptor was associated with both obesity and type 2 diabetes in a large Japanese sample.
尽管已有大量研究，但β3 - 肾上腺素能受体基因的色氨酸64精氨酸多态性与肥胖症和2型糖尿病之间的关联尚未明确阐明。我们在一个基于人群的大样本中研究了这种关联。
来自船形糖尿病研究队列人群（n = 3706）的1685名受试者（935名女性和750名男性，年龄58.7±12.4岁）根据基因型分为三组：Trp/Trp（n = 1155）、Trp/Arg（n = 486）和Arg/Arg（n = 44）。根据1985年世界卫生组织标准诊断葡萄糖耐量。体重指数（BMI）≥30 kg/m²的受试者被视为肥胖。还研究了与肥胖、糖尿病、高血压和血脂异常相关性状的关联。卡方检验和方差分析分别用于关联研究和评估性状值的差异。
与基因型为Trp/Trp的受试者（肥胖率3.29%，P < 0.001；糖尿病患病率4.16%，P = 0.007）或基因型为Trp/Arg的受试者（肥胖率2.06%，P < 0.001；糖尿病患病率5.97%，P = 0.051）相比，基因型为Arg/Arg的受试者中肥胖和患糖尿病的比例更高（均为13.6%）。在基因型Trp/Arg和Trp/Trp之间，这些疾病的发生率没有显著差异。与肥胖相关的性状，如体脂百分比（28.82±7.95 vs. 25.93±7.21，P = 0.038）和BMI（25.07±3.84 vs. 23.63±3.18，P = 0.018），在基因型为Arg/Arg的组中高于基因型为Trp/Trp的组。
在一个大型日本样本中，β3 - 肾上腺素能受体的基因型Arg/Arg而非Trp/Arg与肥胖症和2型糖尿病均相关。
