Nakanishi H, Takeda H
Jpn J Pharmacol. 1975 Feb;25(1):55-61. doi: 10.1254/jjp.25.55.
The interaction of the junction potentials in response to ortho- and antidromic hypogastric nerve stimulation in mouse vas deferens was studied, using an extracellular recording method. Ortho-dromic repetitive hypogastric nerve stimulation (10 Hz, 5 min) simultaneously depressed the amplitude of the junction potentials in response to both ortho- and anti-dromic hypogastric nerve stimulation (post-te-tanic depression). No time-lag in recovery from the post-tetanic depression was observed between the junction potentials recorded from two separate electrodes, indicating that the proximodistal axonal flow of available transmitter was not involved in the recovery process. Double shocks, with intervals from 10 msec to 1 sec, were applied to the hypogastric nerve. The junction potentials in response to ortho- and ortho-dromic or anti- and anti-dromic double shock were markedly facilitated. On the contrary, the junction potentials in response to ortho- and anti-dromic double shocks were not facilited. The findings indicate that facilitation of the junction potentials is produced by the impulses propagated in the same direction along the terminal axon and also that the origin of the facilitation may be at a pre-junctional site.
采用细胞外记录方法，研究了小鼠输精管中对正交和逆向腹下神经刺激的结电位相互作用。正交重复腹下神经刺激（10Hz，5分钟）同时降低了对正交和逆向腹下神经刺激的结电位幅度（强直后抑制）。从两个单独电极记录的结电位之间，未观察到强直后抑制恢复的时间延迟，这表明可用递质的近端到远端轴突流动不参与恢复过程。对腹下神经施加间隔为10毫秒至1秒的双次刺激。对正交和正交或逆向和逆向双次刺激的结电位明显易化。相反，对正交和逆向双次刺激的结电位未易化。这些发现表明，结电位的易化是由沿终末轴突同向传播的冲动产生的，并且易化的起源可能位于节前位点。
