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人工合成生长抑素对人体血浆中内毒素诱导的生长激素、皮质醇和胰岛素变化、血糖及血液白细胞的影响。

Effects of synthetic somatostatin on endotoxin-induced changes of growth hormone, cortisol and insulin in plasma, blood sugar and blood leukocytes in man.

作者信息

Wagner H, Zierden E, Hauss W H

出版信息

Klin Wochenschr. 1975 Jun 1;53(11):539-41. doi: 10.1007/BF01468760.

DOI:10.1007/BF01468760
PMID:1152345
Abstract

In normal man synthetic somatostatin inhibits the growth hormone response to intravenous administration of endotoxin (Piromen), but exerts no influence on cortisol plasma levels. Endotoxin-induced leukocytosis in blood is significantly reduced by somatostatin. Plasma levels of insulin and the blood sugar in man receiving endotoxin are firstly reduced in a significant manner and then increasing to normal values during somatostatin infusion.

摘要

在正常人中，合成生长抑素可抑制静脉注射内毒素（派罗欣）后生长激素的反应，但对血浆皮质醇水平无影响。生长抑素可显著降低内毒素诱导的血液白细胞增多。在内毒素注射的受试者中，胰岛素血浆水平和血糖首先显著降低，然后在生长抑素输注期间升至正常水平。

相似文献

1
Effects of synthetic somatostatin on endotoxin-induced changes of growth hormone, cortisol and insulin in plasma, blood sugar and blood leukocytes in man.人工合成生长抑素对人体血浆中内毒素诱导的生长激素、皮质醇和胰岛素变化、血糖及血液白细胞的影响。
Klin Wochenschr. 1975 Jun 1;53(11):539-41. doi: 10.1007/BF01468760.
2
Comparison of the effect of the pyrogens, etiocholanolone and bacterial endotoxin on plasma cortisol and growth hormone in man.热原、本胆烷醇酮及细菌内毒素对人体血浆皮质醇和生长激素影响的比较。
J Clin Endocrinol Metab. 1968 Mar;28(3):337-42. doi: 10.1210/jcem-28-3-337.
3
Influence of somatostatin on peripheral leucocyte count and granulation tissue in man and rats.生长抑素对人和大鼠外周血白细胞计数及肉芽组织的影响。
Horm Metab Res. 1977 Sep;9(5):378-84. doi: 10.1055/s-0028-1093532.
4
Pituitary and extrapituitary effects of somatostatin in normal man.生长抑素对正常人体垂体及垂体外的作用
Horm Metab Res. 1976 May;8(3):226-31. doi: 10.1055/s-0028-1093646.
5
Growth hormone releasing action of a Pseudomonas endotoxin (piromen).一种假单胞菌内毒素（吡咯霉素）的生长激素释放作用。
Metabolism. 1967 Jan;16(1):57-67. doi: 10.1016/0026-0495(67)90159-x.
6
The effects of calcitonin, somatostatin and hypercalcaemia on metabolic and hormonal indicators during an oral glucose tolerance test (OGTT).降钙素、生长抑素和高钙血症对口服葡萄糖耐量试验（OGTT）期间代谢和激素指标的影响。
Exp Clin Endocrinol. 1987 Mar;89(1):91-6. doi: 10.1055/s-0029-1210632.
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Role of glucagon, catecholamines, and growth hormone in human glucose counterregulation. Effects of somatostatin and combined alpha- and beta-adrenergic blockade on plasma glucose recovery and glucose flux rates after insulin-induced hypoglycemia.胰高血糖素、儿茶酚胺和生长激素在人体葡萄糖反向调节中的作用。胰岛素诱导低血糖后，生长抑素以及α和β肾上腺素能联合阻断对血浆葡萄糖恢复和葡萄糖通量率的影响。
J Clin Invest. 1979 Jul;64(1):62-71. doi: 10.1172/JCI109464.
8
Hyperleptinemia in horses: responses to administration of a small dose of lipopolysaccharide endotoxin in mares and geldings.马的高瘦素血症：小剂量脂多糖内毒素给药对母马和骟马的反应。
J Anim Sci. 2010 Mar;88(3):926-36. doi: 10.2527/jas.2009-2337. Epub 2009 Dec 4.
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Endotoxin injection increases growth hormone and somatostatin secretion in sheep.内毒素注射可增加绵羊体内生长激素和生长抑素的分泌。
Endocrinology. 1998 Jun;139(6):2662-9. doi: 10.1210/endo.139.6.6072.
10
Somatostatin as a tool in studies of basal carbohydrate and lipid metabolism in man: modifications of glucagon and insulin release.生长抑素作为研究人体基础碳水化合物和脂质代谢的工具：对胰高血糖素和胰岛素释放的影响
Scand J Clin Lab Invest. 1974 Dec;34(4):321-5. doi: 10.3109/00365517409049887.

引用本文的文献

1
[Somatostatin -- a review (author's transl)].[生长抑素——综述（作者译）]
Klin Wochenschr. 1976 Apr 1;54(7):293-301. doi: 10.1007/BF01471574.
2
Leukocyte response to somatostatin in normals and patients with bacterial leukocytosis.正常人和细菌性白细胞增多症患者中白细胞对生长抑素的反应。
Klin Wochenschr. 1977 May 15;55(10):503-5. doi: 10.1007/BF01489009.

本文引用的文献

1
COMPARISON OF HEMATOLOGIC AND FEBRILE RESPONSE TO ENDOTOXIN IN MAN.人体对内毒素的血液学反应与发热反应的比较
Blood. 1965 Aug;26:190-201.
2
Specific enzymatic determination of glucose in blood and urine using glucose oxidase.使用葡萄糖氧化酶对血液和尿液中的葡萄糖进行特异性酶法测定。
Diabetes. 1956 Jan-Feb;5(1):1-6. doi: 10.2337/diab.5.1.1.
3
Effect of pyrogen on blood levels of pituitary trophic hormones. Observations of the usefulness of the growth hormone response in the detection of pituitary disease.热原对垂体促激素血水平的影响。关于生长激素反应在垂体疾病检测中的有用性的观察。
J Clin Endocrinol Metab. 1967 Feb;27(2):219-26. doi: 10.1210/jcem-27-2-219.
4
Radioimmunoassay of human growth hormone using the double antibody technique.采用双抗体技术对人生长激素进行放射免疫测定。
Acta Endocrinol (Copenh). 1968 Apr;57(4):549-56. doi: 10.1530/acta.0.0570549.
5
Coated charcoal immunoassay of insulin.胰岛素的包被炭免疫测定法。
J Clin Endocrinol Metab. 1965 Oct;25(10):1375-84. doi: 10.1210/jcem-25-10-1375.
6
Acute suppression of insulin and glucose levels by synthetic somatostatin in normal human subjects.合成生长抑素对正常人类受试者胰岛素和葡萄糖水平的急性抑制作用。
J Clin Endocrinol Metab. 1974 May;38(5):913-5. doi: 10.1210/jcem-38-5-913.
7
Inhibition of growth hormone release in humans by somatostatin.生长抑素对人体生长激素释放的抑制作用。
J Clin Endocrinol Metab. 1973 Oct;37(4):632-4. doi: 10.1210/jcem-37-4-632.
8
Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone.抑制免疫反应性垂体生长激素分泌的下丘脑多肽。
Science. 1973 Jan 5;179(4068):77-9. doi: 10.1126/science.179.4068.77.
9
Specific inhibition by somatostatin of growth hormone release after hypoglycaemia in normal man.正常人体内低血糖后生长抑素对生长激素释放的特异性抑制作用
Clin Endocrinol (Oxf). 1974 Oct;3(4):411-5. doi: 10.1111/j.1365-2265.1974.tb02815.x.
10
Effects of somatostatin on plasma glucose and glucagon levels in human diabetes mellitus. Pathophysiologic and therapeutic implications.生长抑素对人类糖尿病患者血糖及胰高血糖素水平的影响。病理生理学及治疗意义。
N Engl J Med. 1974 Sep 12;291(11):544-7. doi: 10.1056/NEJM197409122911102.