Gugler R, Azarnoff D L, Shoeman D W
Klin Wochenschr. 1975 May 1;53(9):445-6. doi: 10.1007/BF01493371.
The unbound fraction of diphenylhydantoin is inversely correlated with the patient's serum albumin concentration and can be accurately estimated graphically without binding analyses. The data for this relationship was obtained from a study in which we observed that the unbound fraction of diphenylhydantoin was two times higher in patients with the nephrotic syndrome. However, in these patients it was not necessary to diminish the dosage since the absolute concentration of unbond drug was unchanged due to a compensatory increase in the apparent volume of distribution and plasma clearance.
苯妥英的游离分数与患者的血清白蛋白浓度呈负相关，且无需进行结合分析即可通过图表准确估算。这种关系的数据来自一项研究，在该研究中我们观察到，肾病综合征患者的苯妥英游离分数高出两倍。然而，在这些患者中无需减少剂量，因为由于表观分布容积和血浆清除率的代偿性增加，游离药物的绝对浓度并未改变。
