Lee R
University of Texas Southwestern Medical School, Dallas 75390-8889, USA.
Am J Med Sci. 2001 Aug;322(2):88-102. doi: 10.1097/00000441-200108000-00007.
Factor V Leiden is the most prevalent genetic thrombophilia in people of European descent. Since its discovery, much clinical information has been gathered regarding the distribution and prevalence of the genetic mutation, the mechanism of thrombophilia, and its association with clinical thromboembolic events. Although its association with venous thromboembolism is clear, the role of Factor V Leiden in other disease states is not clear. A review of the literature regarding the mechanism of hypercoagulability, genetic versus functional diagnostic tests, screening issues, relationship to arterial thromboses, pregnancy and pregnancy complications, and treatment are discussed.
因子V莱顿突变是欧洲裔人群中最常见的遗传性易栓症。自发现以来，已经收集了许多关于该基因突变的分布和患病率、易栓症机制及其与临床血栓栓塞事件关联的临床信息。尽管其与静脉血栓栓塞的关联很明确，但因子V莱顿突变在其他疾病状态中的作用尚不清楚。本文将对有关高凝机制、基因检测与功能检测、筛查问题、与动脉血栓形成的关系、妊娠及妊娠并发症以及治疗等方面的文献进行综述。
