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狭窄冠状动脉搭桥移植物中不稳定流动的数值模拟

Numerical simulations of unsteady flows in a stenosed coronary bypass graft.

作者信息

Deplano V, Bertolotti C, Boiron O

机构信息

Laboratoire de Biomécanique Cardiovasculaire, Technopĵle de Château Gombert, Marseille, France.

出版信息

Med Biol Eng Comput. 2001 Jul;39(4):488-99. doi: 10.1007/BF02345372.

Abstract

Using the finite element method, physiological blood flows through a three-dimensional model of a coronary graft are numerically analysed. The model includes a stenosis shape in the host artery upstream from the anastomosis. Recirculating areas, secondary flows, wall shear stress (WSS) and spatial wall shear stress gradients (WSSGs) are studied for different flow repartitions and at different times in the cycle. The temporal and spatial evolutions of the recirculating areas downstream from the stenosis, their interactions with the flow issued from the graft and their associated WSSs highlight that the presence of the stenosis in the recipient artery is essential for prediction of the evolution of a grafting at the beginning of its implantation. The areas downstream from the stenosis expansion, non-existent for a host artery without stenosis, are submitted to low and oscillating WSS between -0.5 and 0 Nm(-2). The stagnation point on the recipient artery floor is subjected to high positive and negative WSSGnd values, and its location is dependent on the residual flow through the stenosis.

摘要

采用有限元方法,对冠状动脉移植物三维模型中的生理性血流进行了数值分析。该模型包括吻合口上游宿主动脉中的狭窄形状。针对不同的血流分配和心动周期的不同时刻,研究了再循环区域、二次流、壁面剪应力(WSS)和空间壁面剪应力梯度(WSSG)。狭窄下游再循环区域的时空演变、它们与移植物流出的血流的相互作用以及它们相关的WSS表明,受体动脉中狭窄的存在对于预测移植物植入初期的演变至关重要。狭窄扩张下游的区域(无狭窄的宿主动脉不存在此区域)承受-0.5至0 Nm(-2)之间的低且振荡的WSS。受体动脉底部的驻点承受高的正负WSSGnd值,其位置取决于通过狭窄的残余血流。

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