Buckland M E, Scolyer R A, Donellan M B, Brew S, McGee-Collett M, Harper C G
Department of Anatomical Pathology, Royal Prince Alfred Hospital and Sydney, NSW, Australia.
Pathology. 2001 Aug;33(3):386-9.
Malignant myeloid blast cells may occasionally form a solid mass in tissues outside the haemopoietic system. These tumours are known as chloromas or granulocytic sarcomas. Chloromas occur most commonly in the context of acute myelogenous leukaemia but, rarely, they occur in the absence of other haematological disease, and may be misdiagnosed as lymphoma. A case of a previously well 35-year-old woman presenting with rapidly progressive triplegia caused by a paraspinal and extradural cervical chloroma with no evidence of bone marrow or other haematological involvement is described. Few cases of spinal cord compression caused by chloroma in otherwise healthy patients have been reported. Morphological features of myeloid differentiation, histochemistry and immunohistochemistry, may all aid in rapid diagnosis and allow early and appropriate therapy.
恶性髓系原始细胞偶尔可在造血系统外的组织中形成实体肿块。这些肿瘤被称为绿色瘤或粒细胞肉瘤。绿色瘤最常发生于急性髓系白血病的背景下,但很少在无其他血液系统疾病的情况下发生,且可能被误诊为淋巴瘤。本文描述了一例35岁既往健康的女性患者,因脊柱旁和硬膜外颈部绿色瘤导致快速进展的三肢瘫,且无骨髓或其他血液系统受累的证据。在其他方面健康的患者中,由绿色瘤引起脊髓压迫的病例报道较少。髓系分化的形态学特征、组织化学和免疫组织化学,均有助于快速诊断并实现早期适当治疗。