一名无骨髓受累儿童的脊柱粒细胞肉瘤：病例报告及文献综述
Granulocytic sarcoma of the spine in a child without bone marrow involvement: a case report and literature review.
作者信息
Shiozawa Yusuke, Kiyokawa Nobutaka, Saito Masahiro, Fujimoto Junichiro, Hata Jun-Ichi, Yamashiro Yuichiro
机构信息
Department of Paediatrics, Juntendo University School of Medicine, Tokyo, Japan.
出版信息
Eur J Pediatr. 2005 Oct;164(10):616-20. doi: 10.1007/s00431-005-1728-6. Epub 2005 Jul 13.
UNLABELLED
We report a 2-year-old Japanese boy without bone marrow involvement who developed a primary granulocytic sarcoma in his spinal canal. Tumour cells were positive for myeloperoxidase, MIC2, CD56 and, CD68 on formalin-fixed, paraffin-embedded tissue sections and CD13, CD33, CD45, and CD64 on acetone-fixed fresh frozen sections. Nine months after the initiation of treatment, the tumour had significantly regressed and the patient was able to walk with help.
CONCLUSION
Our patient is the youngest case of granulocytic sarcoma of the spine without bone marrow involvement. Immunohistochemical methods are very helpful in establishing a diagnosis of granulocytic sarcoma.
未标注
我们报告一名2岁日本男孩，无骨髓受累，其椎管内发生原发性粒细胞肉瘤。在福尔马林固定、石蜡包埋组织切片上，肿瘤细胞髓过氧化物酶、MIC2、CD56和CD68呈阳性，在丙酮固定的新鲜冰冻切片上CD13、CD33、CD45和CD64呈阳性。治疗开始9个月后，肿瘤明显消退，患者在帮助下能够行走。
结论
我们的患者是脊柱粒细胞肉瘤且无骨髓受累的最年轻病例。免疫组织化学方法对粒细胞肉瘤的诊断非常有帮助。
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