Hill D G, de Lanerolle P, Heiden D, Aguilar M J, Gerbode F
J Thorac Cardiovasc Surg. 1975 Jul;70(1):133-8.
Ten puppies underwent deep hypothermia with surface cooling and bypass cooling. They were subjected to circulatory arrest for 30 minutes and then were rewarmed by means of bypass. There were 5 control puppies and 5 for which a Swank filter was placed in the arterial perfusion line. All puppies had some degree of lung damage, but it was more severe in those in which perfused blood was not filtered. The damage involved the lung vessels, interstitial tissue, and alveoli. Platelet-fibrin aggregates and margination and sequestration of leukocytes appeared to be important pathological findings. Apparently, the Swank blood filter protects the lung by removing leukocytes and damaged platelets from the circulation.
十只幼犬接受了体表降温及体外循环降温诱导的深度低温。它们经历了30分钟的循环停滞，然后通过体外循环复温。其中5只为对照幼犬，另外5只在动脉灌注管线上放置了斯旺克过滤器。所有幼犬都有一定程度的肺损伤，但在未进行血液过滤的幼犬中损伤更为严重。损伤累及肺血管、间质组织和肺泡。血小板 - 纤维蛋白聚集体以及白细胞的边缘化和扣押似乎是重要的病理表现。显然，斯旺克血液过滤器通过从循环中清除白细胞和受损血小板来保护肺脏。
