DiPaola R S, Patel J, Rafi M M
Dean and Betty Gallo Prostate Cancer Center, New Brunswick, New Jersey, USA.
Hematol Oncol Clin North Am. 2001 Jun;15(3):509-24. doi: 10.1016/s0889-8588(05)70229-x.
The understanding of apoptotic pathways provides new insights into cancer therapy. Therapies that modulate these pathways may induce apoptosis or sensitize tumor cells to other agents. Because many of the components of these pathways are altered in tumor cells compared with normal cells, therapies that target these abnormal apoptotic proteins may be more selective than traditional cytotoxic agents. Difficulties include the translation of the knowledge of these pathways into clinical trials and monitoring the predicted biologic effects in patients. The continued study of new targets, agents capable of modulating these targets, and markers of biologic effect in patients should improve clinical results.
对凋亡途径的理解为癌症治疗提供了新的见解。调节这些途径的疗法可能会诱导细胞凋亡或使肿瘤细胞对其他药物敏感。与正常细胞相比，肿瘤细胞中这些途径的许多成分都发生了改变，因此针对这些异常凋亡蛋白的疗法可能比传统的细胞毒性药物更具选择性。困难包括将这些途径的知识转化为临床试验以及监测患者预期的生物学效应。对新靶点、能够调节这些靶点的药物以及患者生物学效应标志物的持续研究应能改善临床结果。
