Good C D, Johnsrude I S, Ashburner J, Henson R N, Friston K J, Frackowiak R S
Wellcome Department of Cognitive Neurology, Institute of Neurology, London, United Kingdom.
Neuroimage. 2001 Jul;14(1 Pt 1):21-36. doi: 10.1006/nimg.2001.0786.
Voxel-based-morphometry (VBM) is a whole-brain, unbiased technique for characterizing regional cerebral volume and tissue concentration differences in structural magnetic resonance images. We describe an optimized method of VBM to examine the effects of age on grey and white matter and CSF in 465 normal adults. Global grey matter volume decreased linearly with age, with a significantly steeper decline in males. Local areas of accelerated loss were observed bilaterally in the insula, superior parietal gyri, central sulci, and cingulate sulci. Areas exhibiting little or no age effect (relative preservation) were noted in the amygdala, hippocampi, and entorhinal cortex. Global white matter did not decline with age, but local areas of relative accelerated loss and preservation were seen. There was no interaction of age with sex for regionally specific effects. These results corroborate previous reports and indicate that VBM is a useful technique for studying structural brain correlates of ageing through life in humans.
基于体素的形态测量学（VBM）是一种用于在结构磁共振图像中表征区域脑体积和组织浓度差异的全脑、无偏技术。我们描述了一种优化的VBM方法，以研究年龄对465名正常成年人灰质、白质和脑脊液的影响。总体灰质体积随年龄呈线性下降，男性下降更为显著。双侧岛叶、顶上回、中央沟和扣带沟观察到局部加速丢失区域。杏仁核、海马体和内嗅皮质中观察到几乎没有年龄影响（相对保留）的区域。总体白质体积不随年龄下降，但可见局部相对加速丢失和保留区域。年龄与性别在区域特异性影响方面不存在相互作用。这些结果证实了先前的报告，并表明VBM是一种用于研究人类一生中大脑结构与衰老相关性的有用技术。
