Good C D, Johnsrude I, Ashburner J, Henson R N, Friston K J, Frackowiak R S
Wellcome Department of Cognitive Neurology, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom.
Neuroimage. 2001 Sep;14(3):685-700. doi: 10.1006/nimg.2001.0857.
We used voxel-based morphometry (VBM) to examine human brain asymmetry and the effects of sex and handedness on brain structure in 465 normal adults. We observed significant asymmetry of cerebral grey and white matter in the occipital, frontal, and temporal lobes (petalia), including Heschl's gyrus, planum temporale (PT) and the hippocampal formation. Males demonstrated increased leftward asymmetry within Heschl's gyrus and PT compared to females. There was no significant interaction between asymmetry and handedness and no main effect of handedness. There was a significant main effect of sex on brain morphology, even after accounting for the larger global volumes of grey and white matter in males. Females had increased grey matter volume adjacent to the depths of both central sulci and the left superior temporal sulcus, in right Heschl's gyrus and PT, in right inferior frontal and frontomarginal gyri and in the cingulate gyrus. Females had significantly increased grey matter concentration extensively and relatively symmetrically in the cortical mantle, parahippocampal gyri, and in the banks of the cingulate and calcarine sulci. Males had increased grey matter volume bilaterally in the mesial temporal lobes, entorhinal and perirhinal cortex, and in the anterior lobes of the cerebellum, but no regions of increased grey matter concentration.
我们使用基于体素的形态测量法（VBM）来研究465名正常成年人的人脑不对称性以及性别和利手对脑结构的影响。我们观察到枕叶、额叶和颞叶（脑叶）的脑灰质和白质存在显著不对称（脑叶偏位），包括颞横回、颞平面（PT）和海马结构。与女性相比，男性在颞横回和PT内的左侧不对称性增加。不对称性与利手之间没有显著的相互作用，利手也没有主效应。即使在考虑到男性脑灰质和白质的总体积较大之后，性别对脑形态仍有显著的主效应。女性在双侧中央沟深处、左侧颞上沟、右侧颞横回和PT、右侧额下回和额缘回以及扣带回附近的灰质体积增加。女性在皮质、海马旁回以及扣带回和距状沟边缘的灰质浓度广泛且相对对称地显著增加。男性在内侧颞叶、内嗅和嗅周皮质以及小脑前叶的双侧灰质体积增加，但没有灰质浓度增加的区域。
