Borkow G, Weisman Z, Leng Q, Stein M, Kalinkovich A, Wolday D, Bentwich Z
R. Ben-Ari Institute of Clinical Immunology and AIDS Center, Kaplan Medical Center, Hebrew University Hadassah Medical School, Rehovot, Israel.
Scand J Infect Dis. 2001;33(8):568-71. doi: 10.1080/00365540110026656.
Helminth infections affect over a quarter of the world's population, especially in the developing countries. These long-lasting parasitic infections cause widespread immune activation and dysregulation, a dominant Th2 cytokine immune profile and an immune hyporesponsiveness state. Considering these profound immune changes and the similar geographic distributions of helminthic infections, HIV and tuberculosis (TB), we suggest that helminthic infections play a major role in the pathogenesis of AIDS and TB. They apparently make the host more susceptible to infection by HIV and Mycobacterium tuberculosis, and impair his/her ability to generate protective immunity against both infections. The implication of these ideas is that without eradication of helminth infections and/or modulation of the immune changes that they cause, HIV and TB vaccines may fail to confer protection against their respective infections in helminth-endemic areas.
蠕虫感染影响着全球超过四分之一的人口，在发展中国家尤为如此。这些长期的寄生虫感染会导致广泛的免疫激活和失调、占主导地位的Th2细胞因子免疫特征以及免疫低反应状态。考虑到这些深刻的免疫变化以及蠕虫感染、艾滋病毒和结核病（TB）相似的地理分布，我们认为蠕虫感染在艾滋病和结核病的发病机制中起主要作用。它们显然使宿主更容易感染艾滋病毒和结核分枝杆菌，并损害其产生针对这两种感染的保护性免疫的能力。这些观点的含义是，如果不根除蠕虫感染和/或调节它们所引起的免疫变化，艾滋病毒和结核病疫苗可能无法在蠕虫流行地区提供针对各自感染的保护。
