Meironyté Guvenius D, Bergman A, Norén K
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Arch Environ Contam Toxicol. 2001 May;40(4):564-70. doi: 10.1007/s002440010211.
Paired samples of human liver and adipose tissue were analyzed for polybrominated diphenyl ethers (PBDEs) containing 3-6 bromine atoms. The samples were obtained at autopsy from one woman and four men at the age of 47 and 66-83 years, respectively. PBDEs were found in all samples. The sum of nine PBDE congeners ranged 5-18 ng/g lipids and 4-8 ng/g lipids in liver and adipose tissue, respectively. In three paired samples the concentrations were similar in liver and adipose tissue, while in two of the pairs the concentrations were higher in liver than in adipose tissue. The PBDE congeners 2,2',4,4'-tetraBDE (BDE-47), 2,2',4,4',5-pentaBDE (BDE-99), and 2,2',4,4',5,5'-hexaBDE (BDE-153) occurred at highest levels and constituted together 87-96% and 84-94% of the total sum of PBDEs in liver and adipose tissue, respectively. The levels of PBDEs were compared to those of polychlorinated biphenyls (PCBs), polychlorinated naphthalenes (PCNs), 1,1-bis(4-chlorophenyl)-2,2-dichloroethene (p,p'-DDE), and hexachlorobenzene (HCB).
对含有3 - 6个溴原子的多溴二苯醚（PBDEs）进行了人肝脏和脂肪组织配对样本分析。这些样本分别取自一名47岁女性和四名年龄在66 - 83岁男性的尸检样本。所有样本中均检测到PBDEs。肝脏和脂肪组织中九种PBDE同系物的总和分别为5 - 18 ng/g脂质和4 - 8 ng/g脂质。在三对配对样本中，肝脏和脂肪组织中的浓度相似，而在两对样本中，肝脏中的浓度高于脂肪组织。PBDE同系物2,2',4,4'-四溴二苯醚（BDE - 47）、2,2',4,4',5 - 五溴二苯醚（BDE - 99）和2,2',4,4',5,5'-六溴二苯醚（BDE - 153）含量最高，分别占肝脏和脂肪组织中PBDEs总量的87 - 96%和84 - 94%。将PBDEs的含量与多氯联苯（PCBs）、多氯萘（PCNs）、1,1 - 双（4 - 氯苯基）- 2,2 - 二氯乙烯（p,p'-DDE）和六氯苯（HCB）的含量进行了比较。
