Wendlandt J T, Grus F H, Hansen B H, Singer H S
Department of Neurology, Johns Hopkins University School of Medicine, Harvey 811, 600 N. Wolfe Street, Baltimore, MD 21287-8811, USA.
J Neuroimmunol. 2001 Sep 3;119(1):106-13. doi: 10.1016/s0165-5728(01)00370-8.
Antineuronal antibodies have been postulated to be the underlying pathophysiology in TS and other neuropsychiatric disorders. Serum antibodies from 20 children with TS, and 21 control subjects against human striatum, globus pallidus, muscle, and HTB-10 cells were assayed by Western blot techniques. A MANOVA differentiated between TS and control blots, and a discriminant analysis demonstrated which variables contributed most to differences between groups. Prominent differences between TS and control blots were identified using striatal epitopes in contrast to similar patterns shown between groups for globus pallidus, muscle and HTB-10 tissue, supporting striatal autoimmune involvement in TS pathophysiology.
抗神经元抗体被认为是抽动秽语综合征（TS）和其他神经精神疾病潜在的病理生理学机制。采用蛋白质印迹技术检测了20例TS患儿和21例对照受试者血清中针对人纹状体、苍白球、肌肉和HTB - 10细胞的抗体。多变量方差分析区分了TS组和对照组的印迹，判别分析表明哪些变量对两组间差异贡献最大。与苍白球、肌肉和HTB - 10组织在两组间呈现的相似模式相比，利用纹状体表位确定了TS组和对照组印迹之间的显著差异，支持纹状体自身免疫参与TS的病理生理过程。
