Kansy Janice W, Katsovich Liliya, McIver Kevin S, Pick Jennifer, Zabriskie John B, Lombroso Paul J, Leckman James F, Bibb James A
Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA.
J Neuroimmunol. 2006 Dec;181(1-2):165-76. doi: 10.1016/j.jneuroim.2006.08.007. Epub 2006 Oct 2.
Immune responses to beta-hemolytic streptococcal infections are hypothesized to trigger tic disorders and early-onset obsessive-compulsive disorder (OCD) in some pediatric populations. Here we identify the M1 isoform of the glycolytic enzyme, pyruvate kinase (PK) as an autoimmune target in Tourette syndrome and associated disorders. Antibodies to PK reacted strongly with surface antigens of infectious strains of streptococcus, and antibodies to streptococcal M proteins reacted with PK. Moreover, immunoreactivity to PK in patients with exacerbated symptoms who had recently acquired a streptococcal infection was 7-fold higher compared to patients with exacerbated symptoms and no evidence of a streptococcal infection. These data suggest that PK can function as an autoimmune target and that this immunoreactivity may be associated with Tourette syndrome, OCD, and associated disorders.
据推测，对β-溶血性链球菌感染的免疫反应会在一些儿科人群中引发抽动障碍和早发性强迫症（OCD）。在此，我们确定糖酵解酶丙酮酸激酶（PK）的M1亚型是抽动秽语综合征及相关疾病中的一个自身免疫靶点。PK抗体与链球菌感染菌株的表面抗原强烈反应，而抗链球菌M蛋白抗体与PK反应。此外，近期感染链球菌且症状加重的患者对PK的免疫反应性比症状加重但无链球菌感染证据的患者高7倍。这些数据表明，PK可作为一个自身免疫靶点，且这种免疫反应性可能与抽动秽语综合征、强迫症及相关疾病有关。
