抽动秽语综合征的动物模型。
An animal model of Tourette's syndrome.
作者信息
Taylor Jane R, Morshed Syed A, Parveen Salina, Mercadante Marcos T, Scahill Lawrence, Peterson Bradley S, King Robert A, Leckman James F, Lombroso Paul J
机构信息
Child Study Center, Children's Clinical Research Center, School of Nursing, Yale University School of Medicine, New Haven, CT 06520, USA.
出版信息
Am J Psychiatry. 2002 Apr;159(4):657-60. doi: 10.1176/appi.ajp.159.4.657.
OBJECTIVE
An animal model was used to investigate an autoimmune etiology for some cases of Tourette's syndrome.
METHOD
Sera from 12 patients with Tourette's syndrome with high levels of antineural or antinuclear antibodies were infused bilaterally into the ventrolateral striatum of rats. Sera from 12 additional Tourette's syndrome patients and 12 normal subjects (both groups with low levels of autoantibodies) were infused for comparison. Rates of oral stereotypies were recorded by observers who were blind to the origin of the infused sera.
RESULTS
Oral stereotypies significantly increased in the rats infused with sera from the patients with high levels of autoantibodies.
CONCLUSIONS
The results are consistent with an autoimmune etiology in a subset of cases of Tourette's syndrome.
目的
使用动物模型研究部分抽动秽语综合征病例的自身免疫病因。
方法
将12例抗神经或抗核抗体水平高的抽动秽语综合征患者的血清双侧注入大鼠腹外侧纹状体。另外12例抽动秽语综合征患者和12名正常受试者（两组自身抗体水平均低）的血清用于比较。由对注入血清来源不知情的观察者记录口腔刻板行为的发生率。
结果
注入自身抗体水平高的患者血清的大鼠口腔刻板行为显著增加。
结论
结果与部分抽动秽语综合征病例的自身免疫病因一致。
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