Jansson T, Lodén M
TJ Toxikologikonsult, Krysshammarvägen, Solna.
Am J Contact Dermat. 2001 Sep;12(3):166-9.
In spite of extensive self-regulation of the fragrance industry, fragrance ingredients are still major causes of allergic contact dermatitis. There are indications that the problem is increasing in some countries, and that many nonregulated compounds are involved in the development of allergies. The use of essential oils in fragrance compounds might add both allergenic and carcinogenic compounds to a product and the exact composition of such ingredients is difficult to control. Herein, we propose a simple strategy to decrease the risk of adverse effects of fragrance ingredients in cosmetic products. This strategy consists of four major steps: (1) limit the concentration of fragrance compound in the products, (2) follow legislation and guidelines, (3) limit the concentration of a number of well-known sensitizing fragrance chemicals, and (4) limit the concentration of essential oils and materials with unknown composition. The strategy is discussed as an alternative to animal testing and in relation to other more resource-demanding approaches to the same problem.
尽管香料行业进行了广泛的自我监管，但香料成分仍是过敏性接触性皮炎的主要病因。有迹象表明，在一些国家，这个问题正在加剧，而且许多未受监管的化合物都与过敏反应的发生有关。香料化合物中使用精油可能会给产品添加致敏和致癌化合物，而且此类成分的确切组成难以控制。在此，我们提出一种简单的策略，以降低化妆品中香料成分产生不良反应的风险。该策略包括四个主要步骤：（1）限制产品中香料化合物的浓度；（2）遵循法规和指南；（3）限制一些知名致敏香料化学品的浓度；（4）限制精油和成分不明的材料的浓度。本文将讨论该策略，作为动物试验的替代方法，并与针对同一问题的其他资源需求更高的方法进行比较。
