Mitsea A G, Spyropoulos M N
Oral Radiology and Diagnosis Clinic, Dental School, University of Athens, Athens, Greece.
Quintessence Int. 2001 Sep;32(8):639-46.
The purpose of this investigation was to study the development of the premolars in a sample of Greek children with cleft lip and palate.
The study material consisted of panoramic radiographs of 34 individuals (22 boys and 12 girls) with cleft lip with or without cleft palate. The boys ranged from 9.0 to 14.0 years of age and the girls ranged from 8.0 to 14.5 years of age. The mean age was 11.3 years. Each panoramic radiograph was matched with a corresponding one of an unaffected individual of the same sex and chronologic age (+/- 3 months). The panoramic radiographs were used to categorize the stages of tooth development according to the 10 stages of mineralization described by Nolla. The assessment was repeated by a second observer.
Individuals with clefts exhibited a statistically significant delay of formation and mineralization of the maxillary right and left second premolars and the mandibular right second premolar in comparison to individuals without clefts. In the cleft group, there was no statistically significant difference between boys and girls in premolar development. No asymmetric development of contralateral premolar teeth was observed in individuals with cleft lip and palate.
Although the exact biologic explanation remains to be found, the formation of premolars is delayed in children with cleft lip and palate.
本研究旨在调查希腊唇腭裂患儿样本中前磨牙的发育情况。
研究材料包括34例唇裂伴或不伴腭裂患者(22例男性和12例女性)的全景X线片。男性年龄范围为9.0至14.0岁,女性年龄范围为8.0至14.5岁。平均年龄为11.3岁。每张全景X线片均与一名年龄、性别匹配(±3个月)的非唇腭裂个体的相应全景X线片配对。根据Nolla描述的10个矿化阶段,利用全景X线片对牙齿发育阶段进行分类。由另一名观察者重复评估。
与非唇腭裂个体相比,唇腭裂个体上颌左右第二前磨牙和下颌右第二前磨牙的形成和矿化在统计学上有显著延迟。在唇腭裂组中,前磨牙发育在男孩和女孩之间无统计学显著差异。唇腭裂患者未观察到对侧前磨牙的不对称发育。
尽管确切的生物学解释仍有待发现,但唇腭裂患儿前磨牙的形成延迟。