长期摄入含有抗氧化多酚的果汁或果蔬浓缩物期间，HIV血清阳性和健康受试者的血浆抗氧化能力。

Plasma antioxidant capacity of HIV-seropositive and healthy subjects during long-term ingestion of fruit juices or a fruit-vegetable-concentrate containing antioxidant polyphenols.

作者信息

Arendt B M, Boetzer A M, Lemoch H, Winkler P, Rockstroh J K, Berthold H K, Spengler U, Goerlich R

机构信息

School of Medicine, Department of Hemostasis and Transfusion Medicine, University of Düsseldorf, Düsseldorf, Germany.

出版信息

Eur J Clin Nutr. 2001 Sep;55(9):786-92. doi: 10.1038/sj.ejcn.1601227.

DOI:10.1038/sj.ejcn.1601227

PMID:11528495

Abstract

OBJECTIVE

To investigate whether antioxidant polyphenols from fruit juices or a fruit-vegetable-concentrate increase the plasma antioxidant capacity in HIV-infected and healthy subjects.

DESIGN

Twenty-three HIV-seropositive and 18 seronegative adults were randomized to ingest either 1 l of fruit juice or 30 ml fruit-vegetable-concentrate per day over 16 weeks in addition to their normal Western diet.

METHODS

Plasma antioxidant capacity was determined as Trolox equivalent antioxidant capacity (TEAC) at baseline, after 1 and 16 weeks of intervention, and after a 6 week washout.

RESULTS

There was no difference in plasma antioxidant capacity between HIV-infected and healthy subjects at baseline (P=0.1). After 16 weeks of intervention TEAC increased in HIV-positive subjects with both types of polyphenol supplementation (juice, 1.38+/-0.07 to 1.42+/-0.04 mM, P=0.034; concentrate, 1.40+/-0.09 to 1.46+/-0.08 mM, P=0.025). TEAC was not altered by either type of supplementation in HIV-seronegative subjects.

CONCLUSION

Plasma antioxidant capacity can be increased by long-term ingestion of polyphenols from fruit juices or fruit-vegetable-concentrate in HIV-seropositive but not in HIV-seronegative subjects.

SPONSORSHIP

This study was supported by a grant and Cellagon aurum from HG Berner GmbH, Altenholz, and fruit juices from Eckes Granini GmbH & Co. KG, Nieder-Olm.

摘要

目的

研究果汁或果蔬浓缩物中的抗氧化多酚是否能提高HIV感染者和健康受试者的血浆抗氧化能力。

设计

23名HIV血清阳性和18名血清阴性的成年人被随机分配，除正常西方饮食外，在16周内每天饮用1升果汁或30毫升果蔬浓缩物。

方法

在基线、干预1周和16周后以及6周洗脱期后，将血浆抗氧化能力测定为Trolox等效抗氧化能力（TEAC）。

结果

基线时，HIV感染者和健康受试者的血浆抗氧化能力无差异（P=0.1）。在16周的干预后，两种多酚补充剂（果汁，从1.38±0.07毫摩尔增加到1.42±0.04毫摩尔，P=0.034；浓缩物，从1.40±0.09毫摩尔增加到1.46±0.08毫摩尔，P=0.025）均使HIV阳性受试者的TEAC增加。在HIV血清阴性受试者中，两种补充剂均未改变TEAC。