Xia Yongjing, Baum Larry, Pang C P, Siest Gérard, Visvikis Sophie
INSERM U525, Université Henri Poincaré Nancy I, Nancy, France.
Clin Chem Lab Med. 2005;43(8):817-22. doi: 10.1515/CCLM.2005.137.
In order to investigate possible ethnic differences in genetic and environmental determinants, we investigated several cardiovascular disease-associated genetic variations in successful ageing populations of France (Nancy) and China (Hong Kong). Allelic frequencies of these genetic variations were compared between healthy elderly Chinese (n=103) and French populations (n=100). A multi-locus assay was used to genotype 15 genes for 29 biallelic sites, genes implicated in lipid and homocysteine metabolism, thrombosis, leukocyte adhesion, and blood pressure regulation. For most of the candidate markers within lipid metabolism genes, the less frequent alleles were more common in the Chinese population compared with the French population, while the less frequent alleles of the majority of the other markers were detected only or more commonly in the French population. In conclusion, polymorphisms in 13 genes exhibited statistically significant differences in allelic frequencies between the two populations. Since the two populations were selected as examples of successful ageing, we could hypothesise that genetic factors that could play a role in a successful ageing process may be different between the two populations.
为了研究遗传和环境决定因素中可能存在的种族差异，我们在法国（南锡）和中国（香港）的成功老龄化人群中调查了几种与心血管疾病相关的基因变异。比较了健康老年中国人（n = 103）和法国人群（n = 100）之间这些基因变异的等位基因频率。采用多位点分析法对涉及脂质和同型半胱氨酸代谢、血栓形成、白细胞黏附及血压调节的15个基因的29个双等位基因位点进行基因分型。对于脂质代谢基因中的大多数候选标记，与法国人群相比，频率较低的等位基因在中国人群中更为常见，而其他大多数标记频率较低的等位基因仅在法国人群中被检测到或更为常见。总之，13个基因的多态性在两人群之间的等位基因频率上表现出统计学显著差异。由于这两个人群被选作成功老龄化的例子，我们可以推测，在成功老龄化过程中可能起作用的遗传因素在两人群之间可能有所不同。
