Luján-Zilbermann J, Benaim E, Tong X, Srivastava D K, Patrick C C, DeVincenzo J P
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Clin Infect Dis. 2001 Oct 1;33(7):962-8. doi: 10.1086/322628. Epub 2001 Sep 5.
Respiratory virus infections (RVI) have become an increasingly appreciated problem in the hematopoietic stem cell transplant (HSCT) population. A retrospective analysis of 274 patients undergoing 281 HSCT at St. Jude Children's Research Hospital from January 1994 through December 1997 was performed. Medical and clinical laboratory records were reviewed beginning at the onset of conditioning through the year following each HSCT, and the analysis was done for the first RVI only. Thirty-two (11%) of 281 HSCT cases developed a RVI during the first year post-HSCT. The most frequent cause of RVI was human parainfluenza virus type 3. Univariate analysis was performed to determine the association between risk factors and the cumulative incidence of RVI. Respiratory viruses are frequent causes of infections in the first year post-HSCT in the pediatric population. Only allogeneic transplant and the degree of acute or chronic graft versus host disease were found to be statistically significant risk factors for RVI.
呼吸道病毒感染（RVI）在造血干细胞移植（HSCT）人群中已成为一个日益受到重视的问题。对1994年1月至1997年12月在圣裘德儿童研究医院接受281次HSCT的274例患者进行了回顾性分析。从预处理开始至每次HSCT后的一年，对医疗和临床实验室记录进行了审查，且仅针对首次RVI进行分析。281例HSCT病例中有32例（11%）在HSCT后第一年发生了RVI。RVI最常见的病因是3型人副流感病毒。进行单因素分析以确定危险因素与RVI累积发病率之间的关联。呼吸道病毒是儿科人群HSCT后第一年感染的常见病因。仅发现异基因移植以及急性或慢性移植物抗宿主病的程度是RVI的统计学显著危险因素。
