Marovich M A, Lira R, Shepard M, Fuchs G H, Kruetzer R, Nutman T B, Neva F A
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Clin Infect Dis. 2001 Oct 1;33(7):1076-9. doi: 10.1086/322643. Epub 2001 Sep 5.
We describe a patient with very late recurring leishmaniasis recidivans from whom lesional biopsy samples were obtained during and after topical steroid treatment that demonstrated the ability of the host to contain the parasite in the absence of therapy. Combination therapy with intralesional sodium stibogluconate and oral itraconazole was successful and immunologic data suggest that both CD4(+) and CD8(+) T cell subsets had roles in this disease process.
我们描述了一位患有非常晚期复发性皮肤利什曼病的患者，在局部类固醇治疗期间及之后获取了病变活检样本，这些样本显示宿主在未经治疗的情况下有控制寄生虫的能力。病灶内注射葡萄糖酸锑钠和口服伊曲康唑的联合治疗取得了成功，免疫学数据表明CD4(+)和CD8(+) T细胞亚群在这一疾病过程中均发挥了作用。
