Chatproedprai S, Wananukul S
Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Med Assoc Thai. 2001 Jun;84 Suppl 1:S106-10.
An 8-year-old child with cerebral palsy came with progressive purpuric rash affecting the trunk and legs. He had tenderness on palpation of his extremities. Physical examination revealed a moderately pale and cachectic boy. There was bleeding per swollen gums and petichiae on the hard palate. Generalized multiple discrete palpable petichiae spots at hair follicles along the whole body, more on both legs, were observed. He also had tenderness on palpation of his extremities. His hemoglobin was 6.6 g/dl. Platelet count and coagulogram were normal. Roentgenographic findings showed generalized osteoporosis, metaphyseal white line of distal femur, proximal tibia. proximal fibula, distal radius, and distal ulna with submetaphyseal lucency bilaterally. Skin biopsy showed dilated hair follicles, filled with keratinous material and a small corkscrew hair. A diagnosis of scurvy was made; and vitamin C at a dosage of 300 mg per day was given. His swollen gums, bleeding per gums and muscle tenderness improved within 2 days. Perifollicular hemorrhage, follicular hyperkeratosis, and anemia improved in 2 and 3 weeks respectively.
一名8岁脑瘫患儿因躯干和腿部出现进行性紫癜性皮疹前来就诊。他的四肢触诊时有压痛。体格检查发现是一个中度苍白且消瘦的男孩。牙龈肿胀处有出血,硬腭有瘀点。观察到全身沿毛囊分布有多发散在可触及的瘀点,双下肢更多。他的四肢触诊也有压痛。他的血红蛋白为6.6 g/dl。血小板计数和凝血检查正常。X线检查结果显示全身骨质疏松,双侧股骨远端、胫骨近端、腓骨近端、桡骨远端和尺骨远端干骺端出现白色线影,干骺端下透亮。皮肤活检显示毛囊扩张,充满角质物质和一小根螺旋状毛发。诊断为坏血病;给予每日300毫克的维生素C。他牙龈肿胀、牙龈出血和肌肉压痛在2天内有所改善。毛囊周围出血、毛囊角化过度和贫血分别在2周和3周内有所改善。