抗肿瘤抗生素疣孢菌素环缩肽核心的合成策略。

A synthetic strategy for the cyclodepsipeptide core of the antitumor antibiotic verucopeptin.

作者信息

Hale K J, Lazarides L, Cai J

机构信息

The Christopher Ingold Laboratories, Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom.

出版信息

Org Lett. 2001 Sep 6;3(18):2927-30. doi: 10.1021/ol016440s.

DOI:10.1021/ol016440s

PMID:11529792

Abstract

[reaction: see text]. An efficient [2 + 2 + 2]-fragment condensation strategy is described for obtaining the cyclodepsipeptide core of verucopeptin. The 19-membered macrocycle was established through a Carpino HATU mediated macrolactamization, which proceeded in good yield under high-dilution conditions.

摘要

[反应：见正文]。描述了一种用于获得verucopeptin环缩肽核心的高效[2 + 2 + 2]片段缩合策略。通过Carpino HATU介导的大环内酰胺化反应构建了19元大环，该反应在高稀释条件下以良好的产率进行。