Nishiyama Y, Sugawara K, Tomita K, Yamamoto H, Kamei H, Oki T
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
J Antibiot (Tokyo). 1993 Jun;46(6):921-7. doi: 10.7164/antibiotics.46.921.
A new antitumor antibiotic verucopeptin was isolated from the culture broth of Actinomadura verrucosospora Q886-2. It should potent cytotoxicity and specific in vivo activity against B16 melanoma. Maximum T/C value (162%) was obtained by Q1D x 1 treatment schedule.
一种新的抗肿瘤抗生素疣孢菌素从疣孢马杜拉放线菌Q886 - 2的培养液中分离得到。它具有强大的细胞毒性以及对B16黑色素瘤的特异性体内活性。通过每日一次给药、共给药1次的治疗方案,获得了最大T/C值(162%)。