Breton C, Mucha J, Jeanneau C
Centre de Recherches sur les Macromolécules Végétales, Uniiversity Joseph-Fourier, CNRS, BP 53, 38041 Grenoble cedex 9, France.
Biochimie. 2001 Aug;83(8):713-8. doi: 10.1016/s0300-9084(01)01298-6.
Most of the glycosylation reactions that generate the great diversity of oligosaccharide structures of eukaryotic cells occur in the Golgi apparatus. This review deals with the most recent data that provide insight into the functional organization of Golgi-resident glycosyltransferases. We also focus on the recent successes in X-ray crystal structure determination of glycosyltransferases. These new structures begin to shed light on the molecular bases accounting for donor and acceptor substrate specificities as well as catalysis.
产生真核细胞中多种多样寡糖结构的大多数糖基化反应发生在高尔基体中。本综述涉及提供对高尔基体驻留糖基转移酶功能组织深入了解的最新数据。我们还关注糖基转移酶X射线晶体结构测定方面的最新成果。这些新结构开始揭示决定供体和受体底物特异性以及催化作用的分子基础。
