Check J H, Choe J K, Ubelacker L, DiAntonio A
The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, USA.
Clin Exp Obstet Gynecol. 2001;28(3):142-3.
To determine if maternal/paternal sharing of DQ alpha major histocompatibility (MHC) type II antigens is associated with reduced pregnancy and implantation rates following in vitro fertilization-embryo transfer (IVF-ET).
Prospective study with type II MHC DQ alpha alleles detected by polymerase chain reaction (PCR) technology using Perkin Elmer Amyli-type HLA DQ alpha PCR amplification and typing kit. The tests were only performed on patients having their first IVF cycle.
No difference was found in clinical pregnancy rates per transfer between those couples sharing DQ alpha I alleles and those who did not (43.7% vs 40%). There were no spontaneous abortions in the group sharing DQ alpha I alleles.
Maternal/paternal sharing of DQ alpha I antigens does not reduce fecundity following IVF-ET.
确定体外受精 - 胚胎移植（IVF - ET）后，母/父方共享DQα主要组织相容性复合体（MHC）II类抗原是否与妊娠率和着床率降低相关。
采用前瞻性研究，使用珀金埃尔默淀粉样蛋白型HLA DQα聚合酶链反应（PCR）扩增和分型试剂盒，通过PCR技术检测II类MHC DQα等位基因。检测仅在进行首次IVF周期的患者中进行。
共享DQαI等位基因的夫妇与未共享的夫妇相比，每次移植的临床妊娠率无差异（43.7%对40%）。共享DQαI等位基因的组中无自然流产发生。
IVF - ET后，母/父方共享DQαI抗原不会降低生育力。
